12/15/2023 0 Comments Grain free dog food with taurine![]() Moreover, the current foodomics analyses highlight relationships between diet and DCM in dogs that can identify possible etiologies for understanding diet-disease relationships in dogs and humans.ĭilated cardiomyopathy (DCM) is a common, progressive, and “largely irreversible” heart disease affecting humans 1. ![]() Of these ingredients, peas showed the greatest association with higher concentrations of compounds in 3P/FDA diets. Four diet ingredients distinguished the two diet groups (peas, lentils, chicken/turkey, and rice). Random forest analyses identified the top 30 compounds that distinguished the two diet groups with 100% predictive accuracy. Amino acids, amino acid-derived compounds, and xenobiotics/plant compounds were the largest categories of biochemicals that were higher in 3P/FDA diets. We identified 88 named biochemical compounds that were higher in 3P/FDA diets and 23 named compounds that were lower in 3P/FDA diets. We conducted metabolomic profiling of 9 diets associated with canine DCM, containing ≥ 3 pulses, potatoes, or sweet potatoes as main ingredients, and in the top 16 dog diet brands most frequently associated with canine DCM cases reported to the FDA (3P/FDA diets), and 9 non-3P/FDA diets. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs.
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